miR-197, miR-26a and miR-27a analysis in chronic lymphocytic leukemia.
Ana C AndradeTulio R FreitasGeovana G DornelasLorena C GomesBarbara Lf BarbosaSérgio Ss AraújoKarina B GomesAdriano de Paula SabinoPublished in: Biomarkers in medicine (2022)
Aims: Chronic lymphocytic leukemia (CLL) involves the proliferation and increase of B-lymphocytes in the peripheral blood, bone marrow and lymphoid organs. This study evaluated the microRNAs miR-197, miR-26a and miR-27a as potential biomarkers for CLL. Patients & Methods: Eighty-two patients with CLL and 62 control subjects (CT) were investigated for these targets, using quantitative PCR (qPCR). Results: A significant reduction of all microRNAs was observed in CLL compared to the controls (p < 0.001). Significant negative correlations were observed for the clinical staging groups. After adjusting for multiple logistic regression analysis, miR-197 and miR-26a remained as possible independent risk factors related to the CLL. Conclusions: Our data indicated good performance of this microRNAs as potential biomarkers in CLL.
Keyphrases
- chronic lymphocytic leukemia
- cell proliferation
- long non coding rna
- long noncoding rna
- peripheral blood
- bone marrow
- computed tomography
- mesenchymal stem cells
- lymph node
- high resolution
- magnetic resonance
- signaling pathway
- machine learning
- ejection fraction
- artificial intelligence
- electronic health record
- patient reported