Benefits of Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate on COPD Exacerbations, Lung Function, Symptoms, and Quality of Life Across Blood Eosinophil Ranges: A Post-Hoc Analysis of Data from ETHOS.
Mona BafadhelKlaus Friedrich RabeFernando J MartinezDave SinghPatrick DarkenMartin JenkinsMagnus AurivilliusMehul S PatelPaul DorinskyPublished in: International journal of chronic obstructive pulmonary disease (2022)
Benefits of BGF versus GFF were observed across EOS counts, particularly at ≥100 cells/mm³; versus BFF, benefits were largely independent of EOS. These findings confirm that benefits of ICS-containing triple therapy are not restricted to EOS counts ≥300 cells/mm³, supporting recommendations to consider triple therapy in patients with an exacerbation history and EOS counts ≥100 cells/mm³.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- induced apoptosis
- cell cycle arrest
- air pollution
- endoplasmic reticulum stress
- peripheral blood
- cell death
- stem cells
- physical activity
- intensive care unit
- artificial intelligence
- depressive symptoms
- electronic health record
- extracorporeal membrane oxygenation
- replacement therapy
- data analysis