CDK4/6 Inhibition Enhances Oncolytic Virus Efficacy by Potentiating Tumor-Selective Cell Killing and T-cell Activation in Refractory Glioblastoma.

Jingshu XiaoJiaming LiangJunjie FanPanpan HouXiao-Dong LiHaipeng ZhangKai LiLang BuPing LiMiao HeYongheng ZhongLiping GuoPenghui JiaQiaoqiao XiaoJunyu WuHong PengChunmei LiFan XingDe-Ying Guo

Published in: Cancer research (2022)

This study proposes inhibition of cyclin-dependent kinases as a clinically translatable combinatorial strategy to enhance the efficacy of oncolytic virotherapy in GBM.

Keyphrases

cell cycle
single cell
cell therapy
cell proliferation
bone marrow
cell cycle arrest
disease virus