[Determination of zaleplon and clobazam by high performance liquid chromatography - high resolution tandem mass spectrometry using Orbitrap technology].
R A KalekinNatalia E MoskalevaS S BarseghyanA A VolkovaPavel A MarkinS R NevmyatovaSvetlana A AppolonovaPublished in: Sudebno-meditsinskaia ekspertiza (2022)
Was to develop a method for the qualitative and quantitative determination of benzodiazepine receptor agonists (zaleplon and clobazam), taking into account different chemical structures, by high-performance liquid chromatography-high-resolution tandem mass spectrometry using Orbitrap technology for the purposes and tasks of forensic medical examination. A method has been developed for the identification and quantitative determination of zaleplon and clobazam by high-performance liquid chromatography-high-resolution tandem mass spectrometry using Orbitrap technology. The proposed identification method can be used in the future to form a database of domestic mass spectra for potent and narcotic substances.
Keyphrases
- tandem mass spectrometry
- high performance liquid chromatography
- high resolution
- solid phase extraction
- ultra high performance liquid chromatography
- simultaneous determination
- gas chromatography
- molecularly imprinted
- liquid chromatography
- mass spectrometry
- high resolution mass spectrometry
- healthcare
- high speed
- bioinformatics analysis
- working memory
- systematic review
- drinking water