Melittin induces in vitro death of Leishmania (Leishmania) infantum by triggering the cellular innate immune response.
Andreia Vieira PereiraGustavo de BarrosErika Gracielle PintoAndre Gustavo TemponeRicardo de Oliveira OrsiLucilene Delazari Dos SantosSueli CalviRui Seabra FerreiraDaniel Carvalho PimentaBenedito BarravieraPublished in: The journal of venomous animals and toxins including tropical diseases (2016)
The results showed that melittin acts in vitro against promastigotes and intracellular amastigotes of Leishmania (L.) infantum. Furthermore, they can act indirectly on intracellular amastigotes through a macrophage immunomodulatory effect.