Canine prostatic cancer cell line (LuMa) with osteoblastic bone metastasis.
Said M ElshafaeWessel P DirksenAylin A DemirerJustin BreitbachShiyu YuanNoriko KantakeWachiraphan SupsavhadBardes B HassanZayed AttiaLucas B AlstadtThomas J RosolPublished in: The Prostate (2020)
LuMa is a novel canine PCa cell line with osteomimicry and stemness properties. LuMa cells induced osteoblastic bone formation in vitro and in vivo. LuMa PCa cells will serve as an excellent model for studying the mechanisms of osteomimicry and osteoblastic bone and brain metastasis in prostate cancer.
Keyphrases
- prostate cancer
- induced apoptosis
- cell cycle arrest
- vascular smooth muscle cells
- bone mineral density
- radical prostatectomy
- stem cells
- endoplasmic reticulum stress
- cell death
- squamous cell carcinoma
- epithelial mesenchymal transition
- signaling pathway
- diabetic rats
- angiotensin ii
- high glucose
- resting state
- postmenopausal women
- bone loss
- blood brain barrier
- young adults
- pi k akt
- body composition
- subarachnoid hemorrhage
- functional connectivity
- childhood cancer