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Asymmetric Alkene and Arene Halofunctionalization Reactions in Meroterpenoid Biosynthesis.

Bradley S Moore
Published in: Synlett : accounts and rapid communications in synthetic organic chemistry (2017)
Meroterpenoid natural products are important bioactive molecules with broad distribution throughout nature. In Streptomyces bacteria, naphthoquinone-based meroterpenoids comprise a simple yet structurally fascinating group of natural product antibiotics that are enzymatically constructed through a series of asymmetric alkene and arene halofunctionalization reactions. This account article highlights our discovery and characterization of a group of vanadium-dependent chloroperoxidase enzymes that catalyze halogen-assisted cyclization and rearrangement reactions and have inspired biomimetic syntheses of numerous meroterpenoid natural products.
Keyphrases
  • small molecule
  • high throughput
  • solid state
  • single cell