Research on radiotherapy related genes and prognostic target identification of rectal cancer based on multi-omics.

Yi LiuYanguang YangFeng NiGuomei TaiCenming YuXiaohui JiangDing Wang

Published in: Journal of translational medicine (2023)

Five radiosensitivity-related genes related to the prognosis of rectal cancer: TOP2A, MATR3, APOL6, JOSD1, HOXC6, are involved in multiple processes such as immune cell infiltration, immune-related genes, chemosensitivity, signaling pathways and transcriptional regulatory networks and may be potential biomarkers for radiotherapy of rectal cancer.

Keyphrases

rectal cancer
locally advanced
early stage
transcription factor
squamous cell carcinoma
radiation therapy
signaling pathway
single cell
oxidative stress
cell proliferation
endoplasmic reticulum stress