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Adenosine/adenosine type 1 receptor signaling pathway did not play dominant roles on the influence of sodium-glucose cotransporter 2 inhibitor in the kidney of bovine serum albumin-overloaded streptozotocin-induced diabetic mice.

Keiji ShimadaKeizo KanasakiMakoto KatoYoshio OguraYuta TakagakiItaru MonnoTaro HiraiMunehiro KitadaDaisuke Koya
Published in: Journal of diabetes investigation (2022)
A1R signaling activation was not the dominant mechanism on the influence of SGLT2i in the kidney of BSA-overloaded diabetic mice.
Keyphrases
  • diabetic rats
  • signaling pathway
  • oxidative stress
  • protein kinase
  • high glucose
  • pi k akt
  • epithelial mesenchymal transition
  • adipose tissue
  • endothelial cells