XBP1 Activation Reduces Severity of Polycystic Kidney Disease due to a Nontruncating Polycystin-1 Mutation in Mice.

Matteus KrappitzRishi BhardwajKe DongTobias StaudnerDuygu Elif YilmazCarlotta PioppiniParisa WestergerlingDavid RuemmeleTill HollmannThuy Anh NguyenYiqiang CaiAnna-Rachel GallagherStefan SomloSorin Fedeles

Published in: Journal of the American Society of Nephrology : JASN (2022)

Modulating ER chaperone function through XBP1 activity improved Pkd in a murine model of PC1, suggesting therapeutic targeting of hypomorphic mutations.

Keyphrases

polycystic kidney disease
endoplasmic reticulum
high fat diet induced
signaling pathway
cancer therapy
heat shock protein
estrogen receptor
breast cancer cells
heat shock
insulin resistance
wild type
drug delivery
adipose tissue
skeletal muscle
heat stress