A novel stopgain mutation c.G992A (p.W331X) in TACR3 gene was identified in nonobstructive azoospermia by targeted next-generation sequencing.

Dongfeng GengXiao YangRuixue WangShu DengLeilei LiXiaonan HuYuting JiangRuizhi Liu

Published in: Journal of clinical laboratory analysis (2018)

In conclusion, our study revealed a novel stopgain mutation c.G992A (p.W331X) in TACR3 which expanded the mutation spectrum of TACR3 in Chinese NOA infertile men and advanced our understanding of the genetic susceptibility to NOA.

Keyphrases

copy number
genome wide
single cell
middle aged
atrial fibrillation
transcription factor