SCUBE3 Is Likely a Susceptibility Gene for Systemic Lupus Erythematosus for Chinese Populations.

Yuan-Yuan QiYa-Fei ZhaoYa-Ling ZhaiXiao-Xue ZhangXiao-Yang WangXina-Ran LiuYan CuiXiang-Hui Ning Zhan-Zheng Zhao

Published in: Journal of immunology research (2020)

Our research revealed that variants in SCUBE3, which encode SCUBE3 as a TGF-β signaling activator, can be considered as a new genetic susceptibility factor for systemic lupus erythematosus. And the reduced mRNA expression of SCUBE3 was first reported in patients with SLE.

Keyphrases

systemic lupus erythematosus
copy number
disease activity
genome wide
rheumatoid arthritis
single cell
gene expression
dna methylation
inflammatory response