Obesity, clinical, and genetic predictors for glycemic progression in Chinese patients with type 2 diabetes: A cohort study using the Hong Kong Diabetes Register and Hong Kong Diabetes Biobank.

Guozhi JiangAndrea On Yan Luk Claudia Ha-Ting TamEric S LauRisa Ozaki Elaine Y K Chow Alice Pik-Shan KongCadmon K P LimKa Fai LeeShing Chung SiuGrace HuiChiu Chi TsangKam Piu LauJenny Y Y LeungMan-Wo TsangGrace KamIp Tim Lau June K Li Vincent T YeungEmmy LauStanley LoSamuel K S FungYuk Lun ChengChun Chung ChowEwan R PearsonWing Yee SoJuliana Chung Ngor Chan Ronald Ching-Wan Manull nullnull null

Published in: PLoS medicine (2020)

Our results show that approximately 5% of patients with T2D failed OGLDs annually in this clinic-based cohort. The independent associations of modifiable and genetic risk factors allow more precise identification of high-risk patients for early intensive control of multiple risk factors to prevent glycemic progression.

Keyphrases

type diabetes
risk factors
glycemic control
cardiovascular disease
end stage renal disease
newly diagnosed
ejection fraction
genome wide
metabolic syndrome
weight loss
primary care
copy number
prognostic factors
dna methylation
patient reported outcomes
physical activity
high fat diet induced