LRRK2-Associated Parkinsonism With and Without In Vivo Evidence of Alpha-Synuclein Aggregates.
Lana M ChahineDavid-Erick LafontantSeung Ho ChoiHirotaka IwakiCornelis BlauwendraatAndrew B SingletonMichael C BrummRoy N AlcalayKalpana M MerchantKelly Nicole Holohan NudelmanAlain DagherAndrew VoQin TaoCharles S VenutoKarl D KieburtzKathleen L PostonSusan B BressmanPaulina Gonzalez-LatapiBrian AvantsChristopher S CoffeyDanna JenningsEduardo TolosaAndrew D SiderowfKenneth MarekTatyana SimuniPublished in: medRxiv : the preprint server for health sciences (2024)
evidence of CSF alpha-synuclein aggregates. LRRK2 parkinsonism cases without evidence of alpha-synuclein aggregates as a group exhibit less severe motor manifestations and decline may have more significant cognitive dysfunction. The underlying biology in LRRK2-parkinsonism cases without evidence of alpha-synuclein aggregates requires further investigation.