Tau and Aβ42 in lavage fluid of pneumonia patients are associated with end-organ dysfunction: A prospective exploratory study.
Phoibe RenemaJean-Francois PittetAngela P BrandonSixto M LealSteven GuGrace PromerAndrew HackneyPhillip BraswellAndrew PickeringGrace RafieldSarah B VothRon BalczonMike T LinK Adam MorrowJessica BellJonathon P AudiaDiego F AlvarezTroy StevensAndrew B BarkerPublished in: PloS one (2024)
Bacterial infection promotes the generation of cytotoxic tau and Aβ42 within the lung, and these cytotoxins contribute to end-organ dysfunction among critically ill patients. This work illuminates an unappreciated mechanism of injury in critical illness.