Combined electrophysiological and morphological phenotypes in patients with genetic generalized epilepsy and their healthy siblings.
Christina StierMarkus LooseRaviteja KotikalapudiAdham ElshahabiYiwen Li HegnerJustus MarquetandChristoph BraunHolger LercheNiels K FockePublished in: Epilepsia (2022)
EEG detected increased connectivity and power in GGE similar to MEG, but with different spectral sensitivity, highlighting the importance of theta and beta oscillations. Cortical thickness reductions in GGE corresponded to functional imaging patterns. Our multimodal approach extends the understanding of the resting state in GGE and points to genetic underpinnings of the imaging markers studied, providing new insights into the causes and consequences of epilepsy.
Keyphrases
- resting state
- functional connectivity
- high resolution
- working memory
- optical coherence tomography
- genome wide
- copy number
- gene expression
- magnetic resonance
- computed tomography
- dna methylation
- multiple sclerosis
- intellectual disability
- transcranial magnetic stimulation
- photodynamic therapy
- high frequency
- chronic pain
- mass spectrometry
- temporal lobe epilepsy