Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice.
Claudia D FuchsSebastian KrivanecDaniel SteinacherVeronika MlitzAnnika WahlströmMarcus StahlmanThierry ClaudelHubert ScharnaglTatjana StojakovicHanns-Ulrich MarschallMichael TraunerPublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
Presence of hydroxylated BAs result in increased faecal FA excretion and reduced hepatic lipid accumulation. This aggravates development of MCD diet-induced hepatitis potentially by decreasing FXR and PPARα signalling.