5-HT2A receptor-mediated Gαq/11 activation in psychiatric disorders: A postmortem study.

Yuji OdagakiMasakazu KinoshitaJosé Javier Meana Luis F Callado Jesús A García-Sevilla

Published in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2020)

Altered 5-HT2A receptor-mediated signalling pathway through Gαq/11 proteins in prefrontal cortex might be apparently involved in pathophysiology and pharmacotherapy of BP and schizophrenia. In schizophrenic patients, these alterations as a result of successful treatment with antipsychotic agents may help in prevention of suicidal behaviour.

Keyphrases

prefrontal cortex
end stage renal disease
ejection fraction
newly diagnosed
bipolar disorder
chronic kidney disease
peritoneal dialysis
prognostic factors
smoking cessation