EMP2 induces cytostasis and apoptosis via the TGFβ/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma.

Chien-Feng LiTi-Chun ChanCheng-Tang PanPichpisith Pierre VejvisithsakulJia-Chen LaiSzu-Yu ChenYa-Wen HsuMeng-Shin ShiaoYow-Ling Shirley Shiue

Published in: Cellular oncology (Dordrecht) (2021)

EMP2 induces cytostasis via the TGFβ/SMAD/SP1 axis and recruits P2RX7 to enhance apoptosis in UBUC. Our data provide new insights that may be employed for the design of UBUC targeting therapies.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
endoplasmic reticulum stress
oxidative stress
cell cycle arrest
cell death
electronic health record
cancer therapy
big data
pi k akt
signaling pathway