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Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression.

Katherine P MuellerNicole J PiscopoMatthew H ForsbergLouise A SaraspeAmritava DasBrittany RussellMadeline SmerchanskyDan CappabiancaLei ShiKeerthana ShankarLauren SarkoNamita KhajanchiNina La Vonne DenneApoorva RamamurthyAdeela AliCicera R LazzarottoShengdar Q TsaiChristian M CapitiniKrishanu Saha
Published in: Journal for immunotherapy of cancer (2022)
-targeted CAR, which could inform manufacturing of CAR T cells to treat cancers, including solid tumors.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • cell death
  • signaling pathway
  • crispr cas
  • genome wide
  • oxidative stress
  • cancer therapy
  • dna methylation
  • drug delivery
  • young adults
  • childhood cancer