Impact of UGT1A1 gene polymorphisms on plasma dolutegravir trough concentrations and neuropsychiatric adverse events in Japanese individuals infected with HIV-1.

Hiroki YaguraDai WatanabeHiroyuki KushidaKosuke TomishimaHiroaki TogamiAtsushi HiranoMasaaki TakahashiKazuyuki HirotaMotoko IkumaDaisuke KasaiYasuharu NishidaMunehiro YoshinoKunio YamazakiTomoko UehiraTakuma Shirasaka

Published in: BMC infectious diseases (2017)

In addition to younger age, carrying UGT1A1*6 and/or UGT1A1*28 was demonstrated to be a factor associated with high DTG trough concentrations. Our results also suggest a relationship between plasma DTG trough concentrations and NP-AEs, and that carrying UGT1A1*6 and/or UGT1A1*28 alleles might be a risk factor for NP-AEs.

Keyphrases

antiretroviral therapy
hiv infected
hiv positive
hepatitis c virus
hiv aids
hiv testing
south africa
men who have sex with men