Pregnancy Associated Plasma Protein-A and Placental Growth Factor in a Sub-Saharan African Population: A Nested Cross-Sectional Study.

Joyce L BrowneKerstin Klipstein-GrobuschMaria P H KosterDhivya RamamoorthyEdward AntwiIdder BelmoudenArie FranxDiederick E GrobbeePeter C J I Schielen

Published in: PloS one (2016)

PAPP-A and PlGF MoM values appear to be substantially higher in a sub-Saharan African population compared to the Caucasian or Afro-Caribbean MoM values previously reported. The difference suggests the need for a specific correction factor for this population to avoid underestimation of risk for fetal aneuploidies or placental disorders when using PAPP-A and PlGF MoM for screening purposes.

Keyphrases

growth factor
preterm birth
pregnant women
small molecule
amino acid
binding protein
pregnancy outcomes