Telomerase subunit Est2 marks internal sites that are prone to accumulate DNA damage.

Satyaprakash PandeyMona HajikazemiTheresa ZachejaStephanie SchalbetterJonathan BaxterVictor GuryevAndreas HofmannDieter W HeermannStefan A JuranekKatrin Paeschke

Published in: BMC biology (2021)

Our results provide a novel model of telomerase regulation in the cell cycle using internal regions as "parking spots" of Est2 but marking them as hotspots for telomere addition.

Keyphrases

cell cycle
dna damage
cell proliferation
oxidative stress