Impact of STAT1 polymorphisms on crizotinib-induced hepatotoxicity in ALK-positive non-small cell lung cancer patients.

Shuang XinWenfeng FangJianwen LiDelan LiChangzheng WangQuanfei HuangMin HuangWei ZhuangXueding WangLi-Kun Chen

Published in: Journal of cancer research and clinical oncology (2021)

Polymorphism of rs10208033 is a potential biomarker for predicting crizotinib-induced hepatotoxicity. These results suggest that STAT1 plays an important role in crizotinib-induced hepatotoxicity. Further studies are needed to confirm our finding and understand the underlying mechanisms.

Keyphrases

drug induced
high glucose
diabetic rats
advanced non small cell lung cancer
cell proliferation
stem cells
endothelial cells
cell therapy
epidermal growth factor receptor