Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model.

Pablo Ranea-RoblesJorge GalinoLluís EspinosaAgatha SchlüterMontserrat RuizNoel Ylagan CalingasanFrancesc VillarroyaAlba NaudíReinald PamplonaIsidro FerrerM Flint BealManuel Portero-OtinStéphane FourcadeAurora Pujol

Published in: Neuropathology and applied neurobiology (2021)

Together, these findings show that aberrant overactivation of RIP140 promotes neurodegeneration in X-ALD, underscoring its potential as a therapeutic target for X-ALD and other neurodegenerative disorders that present with metabolic and inflammatory dyshomeostasis.

Keyphrases

oxidative stress
mouse model
cerebral ischemia
brain injury
subarachnoid hemorrhage