Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier.
Ruiyi ZhangMengzhou XueVoon Wee YongPublished in: Cells (2021)
Despite marked advances in surgical techniques and understanding of secondary brain injury mechanisms, the prognosis of intracerebral hemorrhage (ICH) remains devastating. Harnessing and promoting the regenerative potential of the central nervous system may improve the outcomes of patients with hemorrhagic stroke, but approaches are still in their infancy. In this review, we discuss the regenerative phenomena occurring in animal models and human ICH, provide results related to cellular and molecular mechanisms of the repair process including by microglia, and review potential methods to promote tissue regeneration in ICH. We aim to stimulate research involving tissue restoration after ICH.
Keyphrases
- brain injury
- stem cells
- subarachnoid hemorrhage
- cerebral ischemia
- mesenchymal stem cells
- cell therapy
- endothelial cells
- cerebrospinal fluid
- inflammatory response
- risk assessment
- type diabetes
- big data
- machine learning
- body mass index
- tissue engineering
- neuropathic pain
- blood brain barrier
- weight loss
- glycemic control