Amitriptyline blocks innate immune responses mediated by TLR4 & IL1R: preclinical and clinical evidence in OA and gout.

Eloi Franco-Trepat Ana Alonso-PérezMaría Guillán-FrescoAlberto Jorge-MoraAntia Crespo-Gomar Miriam López-FagúndezAndrés Pazos-PérezOreste GualilloSusana Belén BravoRodolfo Gomez

Published in: British journal of pharmacology (2021)

We demonstrate amitriptyline's ability to block TLR4-, IL1R- & NLRP3-dependent IIRs. This activity together with clinical data suggest that amitriptyline could be repurposed for systemic or local IIR management in diverse joint inflammatory pathologies.

Keyphrases

immune response
toll like receptor
inflammatory response
dendritic cells
oxidative stress
knee osteoarthritis
electronic health record
stem cells
metabolic syndrome
uric acid
nuclear factor
cell therapy
big data
machine learning
artificial intelligence