Effects of the potassium-sparing diuretic amiloride on chemotherapy response in canine osteosarcoma cells.
Andrew C PoonJordon M InkolAnita K LuuAnthony J MutsaersPublished in: Journal of veterinary internal medicine (2018)
Amiloride synergized with doxorubicin to potentiate apoptosis in canine OSA cells. These results justify further investigation into repurposing of amiloride as an oncology drug for the treatment of OSA in dogs.
Keyphrases
- cell cycle arrest
- induced apoptosis
- cell death
- endoplasmic reticulum stress
- obstructive sleep apnea
- pi k akt
- drug delivery
- palliative care
- heart failure
- emergency department
- squamous cell carcinoma
- positive airway pressure
- rectal cancer
- locally advanced
- atrial fibrillation
- combination therapy
- adverse drug
- replacement therapy