One-Stop Integrated Nanoagent for Bacterial Biofilm Eradication and Wound Disinfection.
Wentao WangWang XuJianquan ZhangYan XuJian ShenNinglin ZhouYuanyuan LiMing ZhangBen-Zhong TangPublished in: ACS nano (2024)
To meet the requirements of biomedical applications in the antibacterial realm, it is of great importance to explore nano-antibiotics for wound disinfection that can prevent the development of drug resistance and possess outstanding biocompatibility. Therefore, we attempted to synthesize an atomically dispersed ion (Fe) on phenolic carbon quantum dots (CQDs) combined with an organic photothermal agent (PTA) (Fe@SAC CQDs/PTA) via a hydrothermal/ultrasound method. Fe@SAC CQDs adequately exerted peroxidase-like activity while the PTA presented excellent photothermal conversion capability, which provided enormous potential in antibacterial applications. Based on our work, Fe@SAC CQDs/PTA exhibited excellent eradication of Escherichia coli (>99% inactivation efficiency) and Staphylococcus aureus (>99% inactivation efficiency) based on synergistic chemodynamic therapy (CDT) and photothermal therapy (PTT). Moreover, in vitro experiments demonstrated that Fe@SAC CQDs/PTA could inhibit microbial growth and promote bacterial biofilm destruction. In vivo experiments suggested that Fe@SAC CQDs/PTA-mediated synergistic CDT and PTT exhibited great promotion to wound disinfection and recovery effects. This work indicated that Fe@SAC CQDs/PTA could serve as a broad-spectrum antimicrobial nano-antibiotic, which was simultaneously beneficial for bacterial biofilm eradication, wound disinfection, and wound healing.
Keyphrases
- staphylococcus aureus
- wound healing
- drinking water
- escherichia coli
- pseudomonas aeruginosa
- metal organic framework
- biofilm formation
- cancer therapy
- quantum dots
- candida albicans
- magnetic resonance imaging
- helicobacter pylori infection
- photodynamic therapy
- microbial community
- mesenchymal stem cells
- nitric oxide
- computed tomography
- silver nanoparticles
- anti inflammatory
- human health