The Role of Epoxyeicosatrienoic Acids in Diabetes Mellitus-Induced Impaired Vascular Relaxation of Aortic Rings in Ovariectomized Sprague-Dawley Rats.

Dragan ManojlovićAna StupinAnita MatićZrinka MihaljevićSanja NovakInes Drenjancevic

Published in: International journal of endocrinology (2019)

Female sex hormones may protect vasorelaxation in type 1 diabetic rats. Type 1 diabetes impairs vasorelaxation in response to ACh in ovariectomized rats (but not in nonovariectomized rats) by affecting vasorelaxation pathways mediated by EETs.

Keyphrases

diabetic rats
oxidative stress
type diabetes
glycemic control
bone loss
cardiovascular disease
left ventricular
insulin resistance
metabolic syndrome
pulmonary artery
high glucose
adipose tissue
endothelial cells
pulmonary arterial hypertension