Genetic Architecture of Acute Myocarditis and the Overlap With Inherited Cardiomyopathy.
Amrit S LotaMark R HazebroekPantazis I TheotokisRebecca WassallSara SalmiBrian P HallidayUpasana TayalJob VerdonschotDevendra MeenaRuth OwenAntonio de MarvaoAlma IacobMomina YazdaniDaniel J HammersleyRichard E JonesRiccardo WageRachel J BuchanFredrik VivianYakeen HafoudaMichela NosedaJohn GregsonTarun MittalJoyce WongJan Lukas RobertusA John BaksiVassilios S VassiliouJoanna TzoulakiAntonis PantazisJohn G F ClelandPaul J R BartonStuart A CookDudley John PennellPablo García-PavíaLeslie T CooperStephane R B HeymansJames Simon WareSanjay K PrasadPublished in: Circulation (2022)
-tv in those with reduced left ventricular ejection fraction. Despite differences between cohorts, these variants have clinical implications for treatment, risk stratification, and family screening. Genetic counseling and testing should be considered in patients with acute myocarditis to help reassure the majority while improving the management of those with an underlying genetic variant.