Extrasynaptic localization is essential for α5GABA A receptor modulation of dopamine system function.
Alexandra M McCoyThomas D PrevotMd Yeunus MianDishary SharminAdeeba N AhmadJames M CookEtienne L SibilleDaniel J LodgePublished in: bioRxiv : the preprint server for biology (2023)
Rs are mostly extrasynaptic. Determining the mechanism of this differential efficacy could lead to the refinement of antipsychotic treatment and improve patient outcomes overall.
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