Histone H3 and TORC1 prevent organelle dysfunction and cell death by promoting nuclear retention of HMGB proteins.

Hongfeng ChenJason J WorkmanBrian D StrahlR Nicholas Laribee

Published in: Epigenetics & chromatin (2016)

TORC1 and histone H3 collaborate to retain HMGBs within the nucleus to maintain cell homeostasis and promote longevity. As TORC1, HMGBs, and H3 are evolutionarily conserved, our study suggests that functional interactions between the TORC1 pathway and histone H3 in metazoans may play a similar role in the maintenance of homeostasis and aging regulation.

Keyphrases

cell death
single cell
transcription factor
oxidative stress
bone marrow
cell proliferation