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Determinants of cognitive impairment in multiple system atrophy: Clinical and genetic study.

Amina NasriAlya GharbiIkram SghaierSaloua MrabetAmira SouissiAmina GargouriMouna Ben DjebaraImen KacemRiadh Goudier
Published in: PloS one (2022)
In this study, the main determinants of CI in Tunisian MSA patients were MSA-P motor-subtype, mainly of PIGD-phenotype, disease duration and APOEε4 carrying status, defining a more altered cognitive phenotype. This effect mainly concerned executive, attention and language functions, all found to be more impaired in APOEε4 carriers with variable degrees across MSA motor-subtypes.
Keyphrases
  • cognitive impairment
  • end stage renal disease
  • working memory
  • ejection fraction
  • cognitive decline
  • newly diagnosed
  • gene expression
  • peritoneal dialysis
  • dna methylation
  • adipose tissue