Abnormalities of mucosal serotonin metabolism and 5-HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron.

David GunnKlara GarsedChing LamGulzar SinghMelanie LingayaVerena WahlBeate NieslerAmanda HenryIan P HallPeter J Whorwell Robin C Spiller

Published in: Alimentary pharmacology & therapeutics (2019)

IBS-D patients have significant abnormalities in mucosal 5-HT metabolism. Those with the lowest concentration of 5-HT in rectal biopsies showed the greatest responsiveness to ondansetron.

Keyphrases

irritable bowel syndrome
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
ulcerative colitis
patient reported outcomes
patient reported
binding protein