SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response.
Kranthi Kiran Kishore TanagalaJoshua Morin-BaxterRichard CarvajalMaryum CheemaSunil DubeyHiroshi NakagawaAngela YoonYi-Shing L ChengAlison TaylorJeffrey NickersonAkiva MintzFatemeh Momen-HeraviPublished in: Journal for immunotherapy of cancer (2023)
Our findings suggest that SP140 could serve as both a therapeutic target and a biomarker to identify immunotherapy responders.