Lumacaftor/ivacaftor changes the lung microbiome and metabolome in cystic fibrosis patients.
Anne H NeerincxKatrine WhitesonJoann L PhanPaul BrinkmanMahmoud I Abdel-AzizEls J M WeersinkJosje AltenburgChristof J MajoorAnke H Maitland-van der ZeeLieuwe D J BosPublished in: ERJ open research (2021)
After starting CF transmembrane conductance regulator (CFTR) modulating treatment in CF patients with a homozygous Phe508del mutation, a temporary and moderate change in the lung microbiome is observed, which is mainly characterised by a reduction in the relative abundance of Pseudomonas aeruginosa.