A role for the NPM1/PTPN14/YAP axis in mediating hypoxia-induced chemoresistance to sorafenib in hepatocellular carcinoma.

Dengke ZhangFazong WuJingjing SongMiaomiao MengXiaoxi FanChenying LuQiaoyou WengShiji FangLiyun ZhengBufu TangYang YangJianfei TuMin XuZhongwei ZhaoJian-Song Ji

Published in: Cancer cell international (2022)

These data suggest that a therapeutic strategy against chemoresistant HCC may involve disruption of NPM1-mediated regulation of YAP by retaining PTPN14 in the nucleus under hypoxic conditions.

Keyphrases

acute myeloid leukemia
electronic health record
big data
machine learning
artificial intelligence
cancer stem cells