Fascin regulates protrusions and delamination to mediate invasive, collective cell migration in vivo.
Maureen C LambKelsey K AnlikerTina L TootlePublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2020)
Overall, Fascin promotes on-time border cell migration during Stage 9 and contributes to multiple aspects of this invasive, collective cell migration, including both protrusion dynamics and delamination. These findings have implications beyond Drosophila, as border cell migration has emerged as a model to study mechanisms mediating cancer metastasis.