The conundrum of differentiating Cushing's syndrome from non-neoplastic hypercortisolism: a systematic review and meta-analysis.
José Miguel Hinojosa-AmayaFernando Díaz González-ColmeneroNeri Alejandro Alvarez-VillalobosAlejandro Salcido-MontenegroCarolina Quintanilla-SánchezPablo José Moreno-PeñaDulce María Manzanares-GallegosLuis Fernando Gutiérrez-DávilaPatricia Lizeth Castillo-MoralesMariano García-CampaJosé Gerardo González-GonzálezElena VarlamovRene Rodriguez-GutierrezMaria FleseriuPublished in: Pituitary (2024)
Dex-CRH, the desmopressin stimulation test, and MSC have similar diagnostic accuracy, with Dex-CRH and MSC having slightly higher sensitivity, and the desmopressin test being more specific. LNSC was the least accurate, probably due to high heterogeneity, intrinsic variability, different assays, and lack of consistent reported cutoffs. When facing this challenging differential diagnosis, the results presented here should increase clinicians' confidence when deciding which test to perform.