Determining the potential targets of silybin by molecular docking and its antibacterial functions on efflux pumps and porins in uropathogenic E. coli.

Shirin Fekri Kohan Alireza Nouhi Kararoudi Maryam Bazgosha Somayeh Adelifar Arman Hafezolghorani Esfahani Fatemeh Ghaderi Barmi Reyhaneh Kouchakinejad Ebrahim Barzegari Mahdi Shahriarinour Najmeh Ranji

Published in: International microbiology : the official journal of the Spanish Society for Microbiology (2024)

Silybin, a safe herbal compound, exhibits potential in inhibiting antibiotic resistance within bacterial isolates, potentially through the regulation of gene expression and plausible binding to target proteins.

Keyphrases

molecular docking
gene expression
escherichia coli
molecular dynamics simulations
human health
signaling pathway
risk assessment
staphylococcus aureus
silver nanoparticles
pseudomonas aeruginosa
cystic fibrosis