Sequential Chromogenic IHC: Spatial Analysis of Lymph Nodes Identifies Contact Interactions between Plasmacytoid Dendritic Cells and Plasmablasts.

Natalie Claudio My-Tien Nguyen Adrian Andreas Wanner Ferdinando Pucci

Published in: Cancer research communications (2023)

We present a comprehensive guide for developing customized biomarker panels to investigate cell-cell interactions in the context of immune responses in cancer. This approach revealed novel contact interactions between plasmablasts and plasmacytoid dendritic cells in lymph nodes from patients with head and neck cancer.

Keyphrases

dendritic cells
lymph node
immune response
single cell
regulatory t cells
cell therapy
sentinel lymph node
neoadjuvant chemotherapy
stem cells
genome wide
gene expression
young adults