Pair Potential between Poloxamer 407 Micelles in 14 wt % Aqueous Solution Clarifying the Sol-Gel-Sol Transition by Temperature Rise.

Poloxamer 407 (P407) is used as a safety-guaranteed, invaluable pharmaceutical nanocarrier. The aqueous solution of P407 exhibits sol-to-gel and gel-to-sol transitions, specifically during a temperature rise. Here, we develop a method to determine the pair potential between colloidal particles based primarily on experimental small-angle scattering data. Using this approach, the pair potential between the P407 micelles in the sol-gel-sol transition state is revealed without prelimiting any type of interaction forces. The results indicate that the increase in the attractive interaction contributes to enhancing the volume fraction, which is the decisive parameter for the gelation in terms of the Alder transition theory, i.e., the fluid-to-crystal phase transition of the hard-sphere model in the micelle system. This study demonstrates that one of the key mechanisms of the gel-to-sol transition upon heating is the enhancement of the structural fluctuation due to widening of the potential well in the intermicellar pair potential.