Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease.

Adriana M HungVictoria A AssimonHua-Chang ChenZhihong YuCaitlyn VlasschaertJefferson L TriozziHelen ChanLee WhelessOtis WilsonShailja C Shah Taralynn M Mack Trevor Thompson Michael E Matheny Saranya Chandrasekar Sahar V MozaffariCecilia P ChungPhilip S Tsao Katalin Suszták Edward D SiewKarol EstradaJ Michael GazianoRobert R Graham Ran Tao Maarten HoekCassianne Robinson-CohenEric M Green Alexander G Bicknull null

Published in: Journal of the American Society of Nephrology : JASN (2023)

APOL1 p.N264K is associated with reduced risk of CKD and ESKD among carriers of APOL1 HR to levels comparable with individuals with APOL1 low-risk genotypes.

Keyphrases

chronic kidney disease
genome wide
gene expression
mouse model
copy number