Electrochemical Detection of Dopamine using a Phenyl Carboxylic Acid-Functionalized Electrode Made by Electrochemical Reduction of a Diazonium Salt.

A glassy carbon electrode (GCE) has been modified by an in situ electrochemical reduction of an aryldiazonium salt generated from the reaction of 4-aminobenzoic acid and sodium nitrite in acidic ethanolic solution. The as-prepared phenyl carboxylic acid-modified glassy carbon electrode has been, for the first time, used for the electrochemical determination of dopamine. Under optimal experimental parameters, outstanding electrocatalytic activity, high sensitivity at a LOD of 5.6×10 -9  m, and broad linearity of 0.1 to 1000 μm were obtained. The crafted electrochemical platform demonstrated excellent stability, specificity, and anti-interference capability towards the sensing of dopamine.