Uncovering the Mechanism of the Xingnaojing Injection against Ischemic Stroke Using a Combined Network Pharmacology Approach and Gut Microbiota Analysis.
Ganlu LiuJingfeng LinLina ZhangQiang GaoZhenyi WangZe ChangYing GaoDayong MaZhen-Yun HanPublished in: Evidence-based complementary and alternative medicine : eCAM (2022)
IS causes dysbiosis of some specific bacteria in the gut microbiota. XNJ is an effective treatment for IS, and its mechanism was related to improving intestinal barrier function and regulating intestinal flora and SCFAs. Network pharmacology revealed that XNJ acts through multiple targets and multiple pathways.