Melatonin induces RAW264.7 cell apoptosis via the BMAL1/ROS/MAPK-p38 pathway to improve postmenopausal osteoporosis.

Xiaochuan WangWen JiangKexin Pan Lin Tao Yue Zhu

Published in: Bone & joint research (2023)

Our study confirmed that melatonin promotes the apoptosis of RAW264.7 cells through BMAL1/ROS/MAPK-p38, and revealed the therapeutic effect and mechanism of melatonin in postmenopausal osteoporosis. This finding enriches BMAL1 as a potential target for the treatment of osteoporosis and the pathogenesis of postmenopausal osteoporosis.

Keyphrases

bone mineral density
postmenopausal women
cell cycle arrest
body composition
cell death
oxidative stress
pi k akt
signaling pathway
induced apoptosis
dna damage
cell proliferation
endoplasmic reticulum stress
reactive oxygen species
combination therapy