Verapamil Inhibits Ser202/Thr205 Phosphorylation of Tau by Blocking TXNIP/ROS/p38 MAPK Pathway.

Mariarosa Anna Beatrice MeloneClemente DatoSimona PaladinoCinzia CoppolaClaudia TrebiniMaria Teresa GiordanaLorena Perrone

Published in: Pharmaceutical research (2018)

Our study unveil a novel pathway involved in AD progression that is inhibited by Verapamil, shedding new light on the understanding of the therapeutic potential of Verapamil in AD.

Keyphrases

cell death
dna damage
nlrp inflammasome
protein kinase
oxidative stress