Long-term physico-chemical stability of 5-fluorouracile at standardised rounded doses (SRD) in MyFuser® portable infusion pump.
Mélanie ClossetSabrina OnoratiMarie-Lise ColsoulNicolas GoderniauxBenoît BihinJacques JamartLaura SoumoyJean-Daniel HecqPascal OdouLaurence GalantiPublished in: Journal of chemotherapy (Florence, Italy) (2021)
Management of chemotherapies is a strategic issue for european healthcare. Dose-banding enables to reduce waiting time of patients in day care units and drug wastage. The aim of this study was to assess the stability of 5-Fluorouracile (5-FU) at standardised rounded doses of 4 and 5 g in MyFuser® portable infusion pump for in-advance preparation. Ten MyFuser® (4 and 5 gr 5-FU added to NaCl 0.9%) were prepared under aseptic conditions and stored at room temperature (23 ± 2 °C) for 28 days then at 30 °C for three days. Physical stability tests were periodically performed: visual and microscopic inspection, pH measurements and optical densities. The concentration of solutions was measured by High Performance Liquid Chromatography/UV detector. Results confirm the stability of 5-FU at selected SRD of 4 g and 5 g with NaCl 0.9% in MyFuser® for at least 28 days at room temperature and three days at 30 °C, allowing in-advance preparation.
Keyphrases
- room temperature
- healthcare
- high performance liquid chromatography
- ionic liquid
- end stage renal disease
- low dose
- chronic kidney disease
- ejection fraction
- mass spectrometry
- tandem mass spectrometry
- physical activity
- palliative care
- simultaneous determination
- prognostic factors
- mental health
- peritoneal dialysis
- solid phase extraction
- ms ms
- emergency department
- low cost
- quality improvement
- social media
- adverse drug