Quantity and Quality of Naturally Acquired Antibody Immunity to the Pneumococcal Proteome Throughout Life.
Marloes VissersMartijn D B van de GardeSamantha W J HeMilou BrandsenRosanne HendriksenMioara Alina NicolaieLarissa van der MaasHugo D MeiringCecile A C M van ElsJosine van BeekNynke Y RotsPublished in: The Journal of infectious diseases (2024)
Humoral immunity against the pneumococcal proteome is acquired through multiple episodes of pneumococcal exposure. Low-level and low-avidity antiproteome antibody profiles in young children may contribute to their IPD susceptibility, while in overall antiproteome antibody-proficient older adults other factors likely play a role.